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From Pixelmon Wiki
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An HP Up is a type of medicine that adds 10 HP EVs to a Pokémon if possible. It also raises a Pokémon's happiness by 5, 3, or 2 depending on how much happiness the Pokémon initially has.

It can be obtained as a tier 2 special drop. It can also be crafted in an Infuser with 10 Sitrus Berries and a Health Feather.

10xSitrus Berry

Health Feather

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