A Toxic Orb is a held item that badly poisons (like Toxic) the holder at the end of a turn if the holder is in battle. It can be obtained as a tier 2 special drop. It is a possible drop from uncommon and rare boss Pokémon, and from certain wild Pokémon.
Before Reforged, this item had the following recipe. It was removed due to many held items being far too easy to make.